Quality control of protein folding: an overview
نویسندگان
چکیده
منابع مشابه
Protein folding in silico: an overview
built from them. As enzymes, proteins catalyze and regulate a cell's biochemical reactions; as antibodies, they are an important part of the immune system. Proteins differ substantially in size and structure, 1 but chemically, all are long, linear chain molecules, with the 20 naturally occurring amino acids acting as monomers. Locally, the chain of amino acids forms regular structures such as h...
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Biosynthesis of proteins--from translation to folding to export--encompasses a complex set of events that are exquisitely regulated and scrutinized to ensure the functional quality of the end products. Cells have evolved to capitalize on multiple post-translational modifications in addition to primary structure to indicate the folding status of nascent polypeptides to the chaperones and other p...
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in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
15 صفحه اولQuality Control of Protein Folding in the Cytosol
In order to function properly, newly synthesised proteins must rapidly and efficiently attain their native conformations. If they fail to do so, the cell may be adversely affected due to loss of function or toxic gain of function effects of misfolded polypeptides. Effective quality control mechanisms to recognise and eliminate misfolded proteins are thus critical for cell viability. The primary...
متن کاملQuality control of protein folding in extracellular space.
The pathologies of many serious human diseases are thought to develop from the effects of intra- or extracellular aggregates of non-native proteins. Inside cells, chaperone and protease systems regulate protein folding; however, little is known about any corresponding mechanisms that operate extracellularly. The identification of these mechanisms is important for the development of new disease ...
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ژورنال
عنوان ژورنال: FEBS Journal
سال: 2012
ISSN: 1742-464X
DOI: 10.1111/j.1742-4658.2011.08457.x